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Dynamics of m6A RNA methylome during leukemogenesis reveals a role of IGF2BP2-PRMT6-MFSD2A signaling axis in maintaining AML stem cells

NIAID Data Ecosystem2026-05-01 收录

急性髓系白血病

m6ARNA甲基化组

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE210281 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2023-12-05

急性髓系白血病

耐药性机制

Targeting the MYST acetyltransferases are an exciting therapeutic opportunity in acute myeloid leukaemia (AML). Here we define the individual and combined contribution of KAT6A, KAT6B and KAT7, in ran

NIAID Data Ecosystem90

Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia [RNA-Seq]

急性髓系白血病

基因表达分析

A hallmark of acute myeloid leukemia (AML) is the inability of self-renewing malignant cells to mature into a non-dividing terminally differentiated state. To better understand how chromatin factors s

干细胞与再生医学数据中心2022-02-20 更新60

Data supporting the publication: Transcriptomic analysis of glycolytic regulation by lncRNAs in acute myeloid leukemia

急性髓系白血病

长链非编码RNA

Acute myeloid leukemia (AML), a high-mortality malignancy, limits the efficacy of traditional therapies due to high heterogeneity. Glycolysis drives AML progression via the tumor microenvironment, but

DataCite Commons2026-03-16 更新50

Aberrant expression of T cell activation markers and upregulation of Tregs in bone marrow and peripheral blood in acute myeloid leukemia patients

急性髓系白血病

免疫学

T cells’ function and activation and the immunosuppressive effect of regulatory T cells (Tregs) play a pivotal role in the occurrence and progression of acute myeloid leukemia (AML). In this study, we

Mendeley Data2024-06-25 更新80

CARM1/PRMT4 is essential for myeloid leukemogenesis but dispensable for normal hematopoiesis

急性髓系白血病

RNA-seq转录组学

We investigated the role of PRMT4 in normal and malignant hematopoiesis. We found that knockdown of PRMT4 impairs cell cycle progression, induces apoptosis, and downgretulateds E2F target genes in leu

NIAID Data Ecosystem50

Dynamics of m6A RNA methylome during leukemogenesis reveals a role of IGF2BP2-PRMT6-MFSD2A signaling axis in maintaining AML stem cells

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