Gene expression changes of n-nitrosodimethylamine-induced in renal cortex of rats

This study is to develop a short term and highly accurate prediction method of renal carcinogenicity based on gene expression profile of rats administrated by carcinogens. We conducted 28 days-repeated dose experiments in male SD rats with n-nitrosodimethylamine, and the gene expression profiles of renal cortex were analyzed using custom microarrays.本研究旨在建立一种基于致癌物染毒大鼠基因表达谱的短期高精度肾脏致癌性预测方法。本研究采用N-亚硝基二甲胺（n-nitrosodimethylamine）对雄性SD大鼠开展28天重复染毒实验，并通过定制微阵列（custom microarray）分析了大鼠肾皮质的基因表达谱。