Adalimumab therapy restores the gut microbiota in patients with ankylosing spondylitis

In this study, we aimed to explore alterations in the gut microbiome that occur during adalimumab therapy and their relationship with the treatment response. We evaluated the gut microbial features of 30 patients with AS who received adalimumab treatment for 6 months and 24 healthy controls. Microbial genomic DNA was extracted from fecal samples and 16S rRNA V4 gene sequencing was performed using the Illumina Hiseq2500 platform.