In vivo evolution of high-level cefiderocol resistance of NDM-1-producing Klebsiella pneumoniae under antibiotic treatment, followed by intra-hospital cross-transmission

We report on the in vivo emergence of cefiderocol resistance mediated by CirA mutation in an NDM-producing K. pneumoniae following cefiderocol treatment, followed by intra-hospital dissemination of the resistant mutants at Udine University hospital