Development of 3D X-ray phase-contrast Imaging and Analysis Tools for Tubular and Branching Structures with Applications in Colorectal Cancer Research

Data and analysis software scripts supporting the PhD University of Southampton Doctoral thesis titled 'Development of 3D X-ray phase-contrast Imaging and Analysis Tools for Tubular and Branching Structures with Applications in Colorectal Cancer Research' (DOI: 10.5258/SOTON/T0026). The dataset is organised following the chapter structure of the thesis: Chapter 2: Data collected during an animal study (Azoxymethane and Dextran Sodium Sulphate mouse model for colorectal cancer). Chapter 3:Plots of the refractive index of paraffin wax and soft tissue. X-ray phase-contrast micro-computed tomographic (μCT) experiment to measure to optimise spatial resolution. Chapter 4:The "3D cyclorama" software that unrolls/flattens deformed tubes of non-uniform thickness. Chapter 6:Data supporting the 3D morphological quantification of crypt budding in early-stage colorectal cancer in the mouse model of chapter 2. Appendix A1:Data produced for the validation of the "3D cyclorama" software. Appendix B:Data and scripts to compute the thickness of individual tissue layers in the murine colon, as well as the number of budding and non-budding crypts found in each μCT scan.