Crystal structure of NRas-G12D in complex with GDP and compound 5

Crystal structure of NRas-G12D in complex with GDP and compound 5 Descriptor: (4P)-4-{3-[(1S,4S)-2,5-diazabicyclo[2.2.2]octan-2-yl]-7-fluoro-1-methyl-1H-pyrazolo[4,3-c]pyridin-6-yl}-5-ethynyl-6-fluoronaphthalen-2-ol, CITRIC ACID, GTPase NRas, ... Authors: Johnson, T.A, Cross, J.B. Deposit date: 2025-08-31 Release date: 2026-02-25 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Structure-Guided Development of NRAS G12D Inhibitors Based on a 5‐Azaindole Core. Acs Med.Chem.Lett., 17, 2026