Location and timing of expression of C. elegans PP2A/4/6 genes.

Genes listed in this table correspond to the following three groups: 1) those encoding members of the holoenzyme complexes that we propose in Fig 9; 2) T22D1.5 and F43B10.1, orthologs of PP2B” regulatory subunits that we found to be necessary for the age-dependent increase in DAF-16 transcriptional activity; and 3) orthologs of regulatory proteins. daf-16 expression information is included as a reference. Expression of genes in tissues where DAF-16 function has been explicitly tested in previous studies, including body wall muscle, intestine, and neurons, are highlighted by coloring the names of those tissues (red, green, and blue, respectively) in the “Anatomical sites of expression” column. (XLSX)