CATH-KinFams: CATH Protein Kinase classification alignments and Hidden Markov Models

CATH KinFams are protein kinase domain families classified according to functional similarity based on SDP. In this deposition we make available 2,210 KinFams sequence alignments alongside Hidden Markov Models built from them to be used with HMMER3. A concatenated library 'kinases_4.3-FF-seed.hmm' is also available to scan against the whole KinFams dataset. The Zenodo deposition contains: kinfams-cath-4.3-seed-alignments.tar.gz - KinFams FASTA file alignments with headers 'UniProt_ID/start-stop' i.e. A8XMX4/281-587 kinfams-cath-4.3-seed-hmms.tar.gz - HMMs for each individual KinFam and concatenated in a HMM library. kinfams-cath-4.3-seed-mda-strings - Multi-Domain-Architecture string assignment for each sequence in the KinFams dataset. human_kinfams_af2_models_cif.tar.gz - Chopped mmCIF files containing Human Kinases AlphaFold2 Models.