Relationship between hormone levels in blood and CYP21A2 haplotype carrier groups in subjects with non-functioning adrenal incidentaloma.

c5/o and c8/0 indicate the carriers (heterozygotes) of CYP21A2 haplotypes of cluster ih5 and cluster ih8, respectively, o/o abbreviates the genotypes of other haplotypes, and N indicates the number of subjects. K-S – Kolmogorov-Smirnov test, ANOVA – analysis of variance, K-W – Kruskal-Wallis test, M-W – Mann-Whitney test. The normalities of hormone datasets were checked by the K-S test; the datasets passing the normality test were investigated by ANOVA and t-test; the datasets not passing were examined by M-W and K-W tests. Median values are represented, interquartile ranges are shown in parentheses below the median values, ns means non-significant result, and significant values (p0.8) are highlighted in bold characters. ACTH – adrenocorticotrophic hormone.ap values of the Newman-Keuls post-hoc test were 0.0263 between c5/o and o/o, 0.0411 between c8/o and o/o and 0.0002 between c5/o and c8/o.bPower was calculated by simulation.cp values of the Newman-Keuls post-hoc test were 0.0814 between c5/o and o/o, 0.7173 between c8/o and o/o and 0.0729 between c5/o and c8/o.dp values of the Newman-Keuls post-hoc test were 0.0958 between c5/o and o/o, 0.1610 between c8/o and o/o and 0.8720 between c5/o and c8/o.Relationship between hormone levels in blood and CYP21A2 haplotype carrier groups in subjects with non-functioning adrenal incidentaloma.