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Investigate the role of B cell in response to anti-PD1 + anti-CTLA in hepatocellular carcinoma

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NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP520080
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资源简介:
B cells may play a critical role in the response to immune checkpoint inhibitor treatment. To investigate the mechanisms, we performed RNA-seq analysis on mouse hepatocellular carcinoma by depleting B-cells and treating with anti-PD1 and anti-CTLA4. Overall design: Mouse HCC model (Hepa1-6 cell, C57BL/6) was developed and treated with isotype or anti-PD1 plus anti-CTLA4 under the candition of WT and B-cell depleition.
创建时间:
2025-09-21
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