CryoEM structure of Gi-coupled TAS2R43 with aristolochic acid I

CryoEM structure of Gi-coupled TAS2R43 with aristolochic acid I Descriptor: 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Kim, Y, Gumpper, R.H, Roth, B.L. Deposit date: 2025-06-03 Release date: 2026-04-22 Last modified: 2026-05-06 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural insights into coffee bitter taste perception by TAS2R43 receptor. Nat.Struct.Mol.Biol., 33, 2026结合马兜铃酸I（aristolochic acid I）的Gi偶联型TAS2R43冷冻电镜结构 描述：8-甲氧基-6-硝基-萘并[1,2-e][1,3]苯并二氧杂环戊烯-5-羧酸、鸟苷酸结合蛋白G(I)/G(S)/G(O)亚基γ-2、鸟苷酸结合蛋白G(I)/G(S)/G(T)亚基β-1等 作者：Kim Y、Gumpper R.H、Roth B.L 提交日期：2025-06-03 发布日期：2026-04-22 最后修改日期：2026-05-06 实验方法：电子显微镜（分辨率2.9 Å） 引用文献：《TAS2R43受体介导咖啡苦味感知的结构机制》，*Nat.Struct.Mol.Biol.*，第33卷，2026年