Iridium-Catalyzed Reduction of Secondary Amides to Secondary Amines and Imines by Diethylsilane
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https://figshare.com/articles/dataset/Iridium_Catalyzed_Reduction_of_Secondary_Amides_to_Secondary_Amines_and_Imines_by_Diethylsilane/2504419
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资源简介：
Catalytic reduction of secondary amides to imines and
secondary
amines has been achieved using readily available iridium catalysts
such as [Ir(COE)2Cl]2 with diethylsilane as
reductant. The stepwise reduction to secondary amine proceeds through
an imine intermediate that can be isolated when only 2 equiv of silane
is used. This system requires low catalyst loading and shows high
efficiency (up to 1000 turnovers at room temperature with 99% conversion
have been attained) and an appreciable level of functional group tolerance.
创建时间：
2016-02-20
