CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244-487)-L6-SRC1(678-692) IN COMPLEX WITH A NOVEL TRICYCLIC-CARBOCYLIC RORGT INVERSE AGONIST
收藏Protein Data Bank Japan2023-10-18 更新2026-03-21 收录
下载链接：
https://pdbj.org/mine/summary/7kqj
下载链接
链接失效反馈官方服务：
资源简介：
CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244-487)-L6-SRC1(678-692) IN COMPLEX WITH A NOVEL TRICYCLIC-CARBOCYLIC RORGT INVERSE AGONIST Descriptor: N-[(3R,3aS,9bS)-9b-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[a]naphthalen-3-yl]-2-hydroxy-2-methylpropanamide, Nuclear receptor ROR-gamma Authors: Sack, J.S. Deposit date: 2020-11-16 Release date: 2021-02-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.645 Å) Cite: Tricyclic-Carbocyclic ROR gamma t Inverse Agonists-Discovery of BMS-986313. J.Med.Chem., 64, 2021
与新型三环碳环类RORγt（RAR-related Orphan Receptor Gamma t）反向激动剂结合的RAR相关孤儿受体C（RAR-related Orphan Receptor C）(NHIS-RORγt(244-487)-L6-SRC1(678-692))的晶体结构
描述符：N-[(3R,3aS,9bS)-9b-[(4-氟苯基)磺酰基]-7-(1,1,1,2,3,3,3-七氟丙-2-基)-2,3,3a,4,5,9b-六氢-1H-环戊并[a]萘-3-基]-2-羟基-2-甲基丙酰胺，核受体ROR-γ
作者：Sack, J.S.
提交日期：2020-11-16
发布日期：2021-02-24
最后修改日期：2023-10-18
实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.645 Å）
引用文献：《三环碳环类RORγt反向激动剂——BMS-986313的发现》，《药物化学杂志》（J.Med.Chem.），第64卷，2021年
创建时间：
2020-11-16
