Genomic Analyses of Human Adenovirus Circulating in Shanghai

Human adenovirus (HAdVs) belongs to the family Adenoviridae and Genus Mastadenovirus, which havebeen grouped into seven species (HAdV-A to G). HAdVs are widespread in the world and infrequent outbreaks are quite common throughout the year. Severe acute respiratory infections, gastroenteritis with dehydration and conjunctivitis are the outcome of fatal HAdV infections. In this study, HAdV-positive respiratory samples from patients with acute respiratory infections were collected inShanghai between 2018 and 2024, we selected some samples for whole genome sequencing.Bioinformatics analyses of these sequences were conducted, providing basic reference data for the development of effective vaccines and public health strategies.