Inhibitory effects of sertraline, duloxetine and amoxapine on GIRK channels.

Mean ± SEM concentrations of antidepressants (µM) that produce 50% of the maximal effect (EC50) and are required to reduce basal GIRK currents by 25% and 50% (IC25 and IC50, respectively) are shown. The % max values indicate the mean ± SEM percentage inhibition of basal GIRK currents by a drug at the highest concentrations tested. The highest concentrations tested (µM) and the number of oocytes tested (n) are shown in parentheses. The nH values indicate the mean ± SEM of Hill coefficients. ND indicates that the value was not determined because of a low effectiveness of the drug.