In mice, genome-wide DNA methylation is actively erased at the onset of fertilisation, followed by remethylation in epiblasts after implantation, leading to inactive chromatin formation as a prelimina

NIAID Data Ecosystem60

Genome-Wide Dynamics of Replication Timing Revealed by In Vitro Models of Mouse Embryogenesis (Expression)

发育表观遗传学

时序控制

Differentiation of mouse embryonic stem cells (mESCs) is accompanied by changes in replication timing. To explore the relationship between replication timing and cell fate transitions, we constructed

NIAID Data Ecosystem40

Long-term metabolic effects of malnutrition: Liver steatosis and insulin resistance following early-life protein restriction

非酒精性脂肪性肝病机制

营养代谢编程

Early postnatal-life malnutrition remains prevalent globally, and about 45% of all child deaths are linked to malnutrition. It is not clear whether survivors of childhood malnutrition suffer from long

NIAID Data Ecosystem70

Hierarchical enhancers 1 confer the temporal and partially compensatory transcriptional regulation of Nkx2-5 during heart development. Hierarchical enhancers 1 confer the temporal and partially compensatory transcriptional regulation of Nkx2-5 during heart development

发育表观遗传学

增强子-基因调控

We comprehensively interrogate enhancers U1 and U2 in controlling Nkx2-5 transcription during heart development. Serial genomic deletions in mice reveal a functional hierarchy of U1 and U2 as evidence

NIAID Data Ecosystem40

Effects of early postnatal overnutrition on the hypothalamic DNA methylation pattern

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