Vaginal microbiome predicts endometrial cancer grade and histology

There is no screening test for endometrial cancer. The vaginal microbiome is a relatively underexplored environment from which both cancer screening and insights about malignant endometrial disease pathophysiology may be achieved. Here, we evaluated the preoperative vaginal microbiome in women undergoing surgery for endometrial cancer to assess if the microbial composition is capable of distinguishing benign, low-grade, and high-grade histologies