p-STAT1 binds p-STAT3

Monocytes express the Interleukin-27 receptor and in response to Interleukin-27 induce Signal transducer and activator of transcription 1-alpha/beta (STAT1) and STAT3 phosphorylation (Pflanz et al. 2004).
Interleukin-27 can induce formation of STAT1/STAT3 heterodimers (Guzzo et al. 2010, Hirahara et al. 2015). Nuclear factor NF-kappa-B (NFkB) is activated by Interleukin-27 stimulation in response to STAT1/STAT3 activation and is essential for Interleukin-27 to activate the production of cytokines (Guzzo et al. 2010).

单核细胞表达白细胞介素-27受体，并在白细胞介素-27的刺激下诱导信号转导和转录激活因子1-α/β（STAT1）及STAT3的磷酸化（Pflanz 等，2004）。白细胞介素-27可诱导STAT1/STAT3异源二聚体的形成（Guzzo 等，2010；Hirahara 等，2015）。在STAT1/STAT3激活的响应下，核因子NF-κB（NFkB）被白细胞介素-27刺激激活，对于白细胞介素-27激活细胞因子的产生至关重要（Guzzo 等，2010）。