Two-/three-dimensional coordination polymers: structural characterization and treatment activity on ulcerative colitis by regulating inflammatory cytokines
收藏Taylor & Francis Group2024-02-16 更新2026-04-16 收录
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https://tandf.figshare.com/articles/dataset/Two-_three-dimensional_coordination_polymers_structural_characterization_and_treatment_activity_on_ulcerative_colitis_by_regulating_inflammatory_cytokines/11847339/1
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资源简介：
In the current study, two new mixed-ligand coordination polymers with the chemical formulae of {[Co(L<sub>1</sub>)<sub>0.5</sub>(oba)·DMF]·DMF·H<sub>2</sub>O} (<b>1</b>, L<sub>1</sub> = <i>N</i>,<i>N</i>′-bis(4-pyridylmethyl)-naphthalene diimide, H<sub>2</sub>oba = 4,4′-oxydibenzoic acid) and [Co(L<sub>2</sub>)<sub>0.5</sub>(OBA)]<i><sub>n</sub></i> (<b>2</b>, L<sub>2</sub> = 1,6-bis(benzimidazolyl)hexane) have been successfully synthesized by the solvothermal reaction of H<sub>2</sub>oba with different flexible N-donor organic ligands in the presence of Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O as the metal source. In addition, the biological functional evaluation of the complexes was performed on the ulcerative colitis (UC) model. First, the enzyme-linked immunosorbent assay detection kit was performed to measure the content of the pro-inflammatory cytokines and anti-inflammatory cytokines after complexes treatment. Next, the UC mice model was constructed and the body weight of the mice was measured and recorded at the 7th and 14th day after complexes treatment at the concentration of 5 mg/kg.
提供机构：
Li, Wei-Xue; Tian, Song-Jun; Ye, Hui; Chen, Xianshe
创建时间：
2020-02-13
