Frontiers in Cell and Developmental Biology_Otis et al. 2024_Data raw

The hypothesis of this preliminary study was that
neuroepigenetics might be modulated by somatosensory
sensitization development (or vice-versa) in an animal model of
chronic OA pain. Taken together, the expression of
neuroepigenetics, neuropeptidomics, and pain phenotype,
particularly QST, would highlight pathophysiological mechanisms
at the peripheral, spinal, and/or supraspinal levels, recognized to be
involved in nociplastic pain. In a prospective,
randomized, blinded, and controlled study, the objectives were to
document parallel changes induced in the MI-RAT OA model on
spinal neuroepigenetics and neuropeptidomics in the non-evoked
expression of musculoskeletal pain, as well as on evoked QST. This would pursue the determination of the MI-RAT as a predictive and
concurrently validated translatable OA model.