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Assembly of Polysubstituted Maleimides via Palladium-Catalyzed Cyclization Reaction of Alkynes with Isocyanides

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https://figshare.com/articles/dataset/Assembly_of_Polysubstituted_Maleimides_via_Palladium-Catalyzed_Cyclization_Reaction_of_Alkynes_with_Isocyanides/4263368
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An efficient and convenient palladium-catalyzed cyclization reaction of alkynes with isocyanides is described herein. This protocol allows the practical synthesis of many valuable polysubstituted maleimide derivatives after hydrolysis with a broad scope of substrates and mild reaction conditions. C–C, CO, and C–N bonds were constructed in this transformation with isocyanide serving as both C and N sources.
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2016-11-28
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