Crystal structure of PPARG and NCOR2 with an inverse agonist (compound 6a)

Crystal structure of PPARG and NCOR2 with an inverse agonist (compound 6a) Descriptor: 2-chloranyl-~{N}-[2-(3-methylphenyl)-1,3-benzoxazol-5-yl]-5-nitro-benzamide, Nuclear receptor corepressor 2, Peroxisome proliferator-activated receptor gamma Authors: Friberg, A, Orsi, D.L, Pook, E, Braeuer, N, Lemke, C.T, Stellfeld, T, Puetter, V, Goldstein, J. Deposit date: 2022-08-12 Release date: 2022-11-09 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery and Structure-Based Design of Potent Covalent PPAR gamma Inverse-Agonists BAY-4931 and BAY-0069 . J.Med.Chem., 65, 2022结合反向激动剂（化合物6a）的PPARG与NCOR2晶体结构 描述符：2-氯-N-[2-(3-甲基苯基)-1,3-苯并噁唑-5-基]-5-硝基苯甲酰胺、核受体辅阻遏蛋白2（Nuclear receptor corepressor 2, NCOR2）、过氧化物酶体增殖物激活受体γ（Peroxisome proliferator-activated receptor gamma, PPARG） 作者：Friberg, A、Orsi, D.L、Pook, E、Braeuer, N、Lemke, C.T、Stellfeld, T、Puetter, V、Goldstein, J. 存放日期：2022-08-12 发布日期：2022-11-09 最后修改日期：2024-10-23 实验方法：X射线衍射（分辨率2.3 Å） 引用文献：Discovery and Structure-Based Design of Potent Covalent PPARγ反向激动剂BAY-4931与BAY-0069，《J.Med.Chem.》，65卷，2022年