Additional file 17: Table S16. of DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas

The differentially methylated CpG sites within de-regulated genes from the comparison between infratentorial pilocytic astrocytomas and normal cerebellum controls. 1_ Features of 11, 671 probes that are significantly differentially methylated in infratentorial pilocytic astrocytomas compared to published foetal and adult normal cerebellum datasets (averaged beta values with a difference of δβ ≥ 0.3, Benjamini-Hochberg corrected p-value <0.05 [Lambert et al, Acta Neuropathologica 126:291-301, 2013]). 2_ Normalized log2 transformed expression analysis identifies differentially expressed genes between infratentorial pilocytic astrocytomas (n = 4) compared to normal cerebellum (n = 2, foetal and adult cerebellum). Genes that show fold change >2 are highlighted. 3_ List of genes that have differential methylation (δβ ≥ 0.3) and differential gene expression (fold change >2). (XLSX 4414 kb)