Effects of L-BAIBA administration and sub-optimal mechanical loading on gene expression in osteocyte-enriched cortical bone

To investigate potential mechanisms for the synergism of L-BAIBA and mechanical loading on bone formation, RNA Seq was performed on osteocyte-enriched cortical bone from mice treated with L-BAIBA and sub-optimal mechanical loading (8.25N) for either long-term (2 weeks L-BAIBA and loading) or short-term (5 days L-BAIBA and a single bout of mechanical loading). Overall design: Comparative gene expression profiling analysis of RNA-seq data from loaded and non-loaded osteocyte-enriched cortical bone from L-BAIBA and control treated mice.