Inhibitors of HCV NS3/4A.
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https://figshare.com/articles/dataset/_Inhibitors_of_HCV_NS3_4A_/285222
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NS3/4A activity was measured using Ac-DE-D(Edans)-EE-Abu-ψ-[COO]-AS-K(Dabsyl)-NH2 as a peptide substrate. The activity of furin and both WNV and DV2 NS2B-NS3 proteinases was measured using pyroglutamic acid-Arg-Thr-Lys-Arg-7-amino-4-methylcoumarin as a substrate. IC50 and IC90, compound concentrations, which reduced viral replication by 50% and 90%, respectively. CC50 and CC90, compound concentrations, which reduced cell viability by 50% and 90%, respectively. >100, determined values exceeded 100 µM. Refer to Table S1 for the compound structures.
创建时间：
2012-07-02
