Composite map of GluA1/A2 in the activated state, in complex with positive allosteric modulator (R,R)-2b and agonist glutamate (ATD-LBD-TMD)

Composite map of GluA1/A2 in the activated state, in complex with positive allosteric modulator (R,R)-2b and agonist glutamate (ATD-LBD-TMD) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, Isoform Flip of Glutamate receptor 1, ... Authors: Yen, L.Y, Sobolevsky, A.I, Newton, T.P, Gangwar, S.P. Deposit date: 2025-05-31 Release date: 2026-04-08 Last modified: 2026-05-20 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Auxiliary subunits reshape structural asymmetry and functional plasticity in heterotetrameric GluA1/A2 AMPA receptor core. Nat Commun, 17, 2026激活状态下GluA1/A2型谷氨酸受体的复合图谱，该复合物与正变构调节剂（positive allosteric modulator）(R,R)-2b及激动剂（agonist）谷氨酸结合（结构域覆盖范围：氨基端结构域-配体结合结构域-跨膜结构域，ATD-LBD-TMD）。 数据集描述项：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、谷氨酸、谷氨酸受体1的Flip剪接变体…… 作者：Yen, L.Y.、Sobolevsky, A.I.、Newton, T.P.、Gangwar, S.P. 提交日期：2025-05-31 发布日期：2026-04-08 最后修改日期：2026-05-20 实验方法：电子显微镜（3.2 Å） 引用文献：辅助亚基重塑异四聚体GluA1/A2型AMPA受体核心的结构不对称性与功能可塑性. 《自然-通讯》, 17, 2026