Loss of Nucleoporin Nup210 Results in Muscle Repair Delays and Age-Associated Alterations in Skeletal Muscle Integrity

This study describes how absence of a member of the nuclear pore complex is important for skeletal muscle maintenance and function but is not required for mammalian muscle development. Transcriptomics comparison of the muscles of Nup210 knockout and wild-type animals by RNA-seq on Quadriceps muscles本研究阐明了核孔复合物（nuclear pore complex）的某一成员缺失对骨骼肌稳态维持与功能发挥具有重要作用，但该成员并非哺乳动物肌肉发育所必需。本研究通过对股四头肌（Quadriceps muscles）开展RNA测序（RNA-seq），对Nup210基因敲除（knockout）与野生型（wild-type）动物的肌肉组织进行了转录组学（transcriptomics）对比分析。