Characteristics and expression of lncRNA in Drosophila aneuploidy

Aneuploidy variation can widely affect the expression of the whole genome, which is detrimental to organisms.Long noncoding RNAs (lncRNAs) are defined as RNAs that are longer than 200 nucleotides and lack a significant open reading frame.Although only a few lncRNAs have been well described, and most of them are still functionally unknown, there is sufficient evidence that lncRNAs have important cellular functions.We provide a comprehensive description of the characteristics and expression profiles of lncRNAs in aneuploid Drosophila. It is found that lncRNAs are sensitive to aneuploidy.Several lncRNAs were investigated for their expression patterns during embryogenesis by fluorescence in situ hybridization.Our results suggest that lncRNAs are affected by genomic imbalance. Overall design: Comapare the global expression of trisomy 2L, metafemale and wildtype Drosophila.