Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus

This study is conducted to investigate the changes of antibiotic susceptibility over time under Vancomycin treatment using Staphylococcus aureus as a model organism. S. aureus is treated with increasing concentrations of Vancomycin and sensitivity/resistance for additional 7 drugs were quantified. Additionally, whole-genome sequencing is done in order to delineate convergent/divergent mutational patterns in Vancomycin intermediate-resistant strains. For additional info/code (https://github.com/KyleCard/S_aureus_evolution)