Effect of depletion of SOD1 on gene expression of organoid culture

To investigate the function of SOD1 in regulation of ISC growth, we established intestinal organoids from tamoxifen–inducible intestinal epithelial cell (IEC)–specific Sod1 knockout (Sod1f/f; Vil-creERT2) mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of Sod1f/f and Sod1f/f;Vil-creERT2 organoids after 3 days of tamoxifen treatment. Organoids were derived from three mice of each genotype. Comparative gene expression profiling analysis of RNA-seq data for control and SOD1 knockout organoids