Acute myeloid leukemia is a hematopoietic malignancy caused by recurrent mutations in genes encoding transcriptional, epigenetic and/or signaling regulators. The t(8;21) translocation generates the ab

干细胞与再生医学数据中心2022-02-20 更新80

Kynurenine engages Serotonin Receptor 1b in osteoblasts to reinforce Acute Myeloid Leukemia

急性髓系白血病

白血病研究

We performed RNAseq analysis of primary human osteoblasts co-cultured with the human THP-1 AML cell-line and, in parallel, RNAseq analysis on the THP-1 AML cells exposed to the human primary osteoblas

NIAID Data Ecosystem40

Transcription control by the ENL YEATS domain in acute leukemia [ChIP-seq]

白血病研究

转录调控

Recurrent chromosomal translocations involving the mixed lineage leukemia gene (MLL) give rise to highly aggressive acute leukemia associated with poor clinical outcomes. The preferential involvement

NIAID Data Ecosystem110

Additional file 5 of Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities

白血病研究

转录因子分析

Additional file 5: Table S4. Supporting information related to SCENIC analysis. Summary of regulons discovered in healthy BM B-lineage analysis (related to Fig. 2) and the related validation motif ana

DataCite Commons2020-11-21 更新40

Murine M7 leukemia derived from retroviral insertional mutagenesis of Gata1s fetal progenitors

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