A proposed working model for the budding yeast PRR pathways.
收藏Figshare2016-02-23 更新2026-04-29 收录
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MRX, in conjunction with Sae2, functions upstream of PCNA monoubiquitination by ssDNA resection thus promoting Rad6-Rad18 to monoubiquitinate PCNA. Exo1 processes ssDNA gaps in the 5′-3′ direction, which facilitates PCNA polyubiquitination by Rad5-Ubc13-Mms2 and subsequent error-free lesion bypass mediated by the Shu complex, HR and Sgs1-Top3 resolution.
创建时间：
2016-02-23
