Cardiovascular diseases and stroke

oleuropein administration improved cerebral edema, hyponatremia, and decreased cardiac dysfunction markers and ACE activities with remarkable mitigation of oxidative stress in brain tissue. Moreover, in silico analysis revealed strong inhibitions of ACE, protein disulfide isomerase (PDI) and TGF-β1 activities. Overall, oleuropein offers neuroprotective, anti-embolic and antioxidative properties in ischemic stroke.橄榄苦苷（oleuropein）给药可改善脑水肿、低钠血症，降低心功能障碍标志物水平与血管紧张素转换酶（ACE）活性，并显著缓解脑组织氧化应激。此外，虚拟实验分析显示其可强效抑制ACE、蛋白质二硫键异构酶（PDI）及转化生长因子β1（TGF-β1）的活性。总体而言，橄榄苦苷在缺血性脑卒中中展现出神经保护、抗栓塞及抗氧化的特性。