6‑Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58‑2

Chemical
investigation of cyanobacterial strain HT-58-2, which most closely
aligns with the genus Brasilomena, has led to the
isolation of two compounds related to tolypodiol. The structures and
absolute configuration of 6-deoxytolypodiol (1) and 11-hydroxytolypodiol
(2) were elucidated by spectroscopic and spectrometric
analysis. While tolypodiol previously showed anti-inflammatory activity
in a mouse ear edema assay, only 2 reduced in
vitro thromboxane B2 and superoxide anion (O2–) generation from Escherichia coli lipopolysaccharide-activated rat neonatal microglia to any appreciable
degree.