Impaired store-operated Ca2+ entry in mouse epidermis

The purpose of this study was to investigate the role of SOCE in the skin epidermis in vivo, using female mice with epithelial tissue-specific Stim1 and Stim2 knockout (Stim1/2 cKO) and control mice (Stim1/2fl/fl). This study found that SOCE dysfunction led to hyperkeratosis and impaired epidermal barrier function via Klk activation without affecting skin cell proliferation in vivo. Overall design: RNA samples collected from keratinocytes obtained from epithelial tissue-specific (K14-Cre) Stim1 and Stim2 knockout (Stim1/2 cKO) and control mice (Stim1/2fl/fl).