Genes whose expression was decreased in RASMC subjected to Na+,K+-ATPase inhibition.

RVSMC were treated with 3 mM ouabain or K+-free medium for 6 hr. Listed are assigned genes whose expression was decreased in K+-free medium by more than 3-fold and was different by less than 2-fold in the presence of ouabain compared to K+-free medium. GeneChip expression analysis was performed as described in the Methods section. mRNA content in control cells was taken as 1.00. Genes whose expression is altered in ischemia/hypoxia are shown in bold. Appearing in parentheses are numbers of citations in PubMed. Given in italics are genes whose differential expression was detected in ischemic tissue by whole genome microarray-based analysis [12]–[18]. Data on gene function from GeneCards database (www.genecards.org) were used for identification of gene function. Functional categories: T– regulators of transcription/translation, RNA processing and degradation; D– regulators of cell adhesion, migration, proliferation, differentiation and death; I– inflammation and immune responses; O – others; U – unknown function.Genes whose expression was decreased in RASMC subjected to Na+,K+-ATPase inhibition.