RNA-sequencing of wild-type and IRF4-deficient splenic cDC2s
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE188832
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We analyzed the transcriptome differences of wild-type and IRF4-deficient (CD11c-cre x Irf4fl/fl) type-2 conventional dendritic cells (cDC2s) in spleen. Wild-type or IRF4-deficient (CD11c-cre x Irf4fl/fl) bone marrow cells were transferred into lethal irradiated CD45.1 mice. 8 weeks later, splenic cDC2s were purified and prepared for RNA-seq analysis. Three technical repeats of ~10^5 cells per sample from each of one mouse were included. CD97 was downregulated in IRF4-deficient cDC2s. GSEA showed that upregulated and downregulated genes in CD97-deficient cells were strongly enriched in IRF4-regulated genes. These data are in accord with CD97 acting within the IRF4 gene-expression network. Transcriptome analysis of WT and CD11c-Cre Irf4fl/fl splenic cDC2s
创建时间：
2022-03-23
