Asymetric GTP bound structure of UPRTase from Sulfolobus solfataricus containing PRPP-mg2+ in half of the active sites and R5P and PPi in the other half

Protein Data Bank Japan2023-11-01 更新2026-03-21 收录

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Asymetric GTP bound structure of UPRTase from Sulfolobus solfataricus containing PRPP-mg2+ in half of the active sites and R5P and PPi in the other half Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 5-O-phosphono-alpha-D-ribofuranose, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Kadziola, A, Christoffersen, S. Deposit date: 2009-02-09 Release date: 2009-09-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural and kinetic studies of the allosteric transition in Sulfolobus solfataricus uracil phosphoribosyltransferase: Permanent activation by engineering of the C-terminus J.Mol.Biol., 393, 2009

硫磺矿硫化叶菌（Sulfolobus solfataricus）来源的尿嘧啶磷酸核糖转移酶（uracil phosphoribosyltransferase, UPRTase）不对称GTP结合结构：该结构的一半活性位点含有5-磷酸核糖-1-焦磷酸-镁离子复合物（phosphoribosyl pyrophosphate-Mg²+, PRPP-Mg²+），另一半活性位点则含有5-磷酸核糖（ribose-5-phosphate, R5P）与焦磷酸（pyrophosphate, PPi）。配体描述：1-O-焦磷酸基-5-O-磷酸基-α-D-呋喃核糖、5-O-磷酸基-α-D-呋喃核糖、鸟苷-5'-三磷酸（guanosine-5'-triphosphate, GTP）…… 作者：Kadziola, A、Christoffersen, S. 入库日期：2009-02-09 发布日期：2009-09-01 最后修改日期：2023-11-01 实验方法：X射线衍射（分辨率2.9埃）引用文献：《硫磺矿硫化叶菌尿嘧啶磷酸核糖转移酶变构转变的结构与动力学研究：通过C端工程化实现永久激活》，《Journal of Molecular Biology》，第393卷，2009年

创建时间：

2009-02-09