RIP1 kinase domain in complex with compound 1

RIP1 kinase domain in complex with compound 1 Descriptor: Receptor-interacting serine/threonine-protein kinase 1, methyl 1-[(2,6-dichlorophenyl)methyl]-1H-pyrazole-3-carboxylate Authors: Lupardus, P, Fong, R, Demircioglu, F.E. Deposit date: 2025-08-15 Release date: 2025-11-12 Last modified: 2025-11-26 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Discovery of Clinical Candidate GDC-8264, a Novel, Potent and Selective RIP1 Inhibitor for Amelioration of Tissue Damage and the Treatment of Inflammatory Diseases. J.Med.Chem., 68, 2025