Transcriptome sequencing of superovulation with the gonadotropin-releasing hormone agonist (GnRHa) trigger in mice

Superovulation is a critical step in assisted reproductive technology, but the use of human chorionic gonadotropin as a trigger for superovulation can result in ovarian hyperstimulation. Thus, the use of Gonadotropin-releasing hormone agonist trigger has been increasingly adopted, although it has been associated with a higher rate of pregnancy failure compared to natural cycles. This study aimed to investigate the effect of GnRHa trigger on embryo implantation in a mouse model.