Whole-Exome and Transcriptome Sequencing Data from Normal and FF Tumor Tissues from Male Patient with Cancer of Unknown Primary

Case Report: The study consisted of a comprehensive genomic and molecular analysis of the Whole Exome Sequencing (WES) and RNA sequencing (RNAseq) data of a cancer of unknown primary (CUP) patient, with a history of rapid progression on empirical chemotherapy. Our profiling approach identified a molecular target, characterized gene expression patterns, the tumor microenvironment composition, and analyzed the origin of the tumor. This led to a personalized treatment strategy, resulting in substantial radiological response across all metastatic sites and the predicted primary site of the tumor.