Supplementary Material for: MRI-guided Focused Ultrasound VIM Thalamotomy with Indwelling GPi DBS Electrodes: A Case Report

Introduction: Deep brain stimulation (DBS) is the gold-standard surgical treatment for Essential Tremor (ET) and Tremor-dominant Parkinson’s Disease (TdPD). However, despite appropriate electrode placement and programming, patients may develop tremor recurrence due to disease progression. MRI-guided focused ultrasound (MRgFUS) thalamotomy is an alternative treatment to DBS and has been shown to yield durable tremor control in both ET and TdPD patients. However, MRgFUS thalamotomy in a patient with indwelling DBS electrodes has not been previously reported.

Case Presentation: We present the case of a 77-year-old male with progressive TdPD who underwent bilateral globus pallidus internus (GPi) DBS with subsequent right unilateral VIM thalamotomy 23 months after DBS due to progressive tremor recurrence. At 6 month follow up, his tremor has completely resolved.

Discussion: This is the first report of MRgFUS thalamotomy for recurrent tremor with indwelling DBS electrodes. We found that MRgFUS thalamotomy as salvage therapy with implanted GPi DBS electrodes is both safe and effective. It represents a novel potential treatment paradigm for TdPD patients with persistent tremor despite otherwise effective GPi DBS.