Effect of restraint stress on gene expression in peripheral blood cells of mice

Psychological stress could affect the immune system and then regulate the disease process. It is generally believed that chronic stress is harmful to health, while acute stress is conducive to life survival. At present, most studies focused on the effects of chronic stress on diseases and immune cells. How acute stress affects the immune system remains poorly understood. In this study, female C57BL/6 mice received restraint stress or no stress for 6 hours. RNA was harvested from peripheral blood and transcriptome sequencing was performed. Overall design: Mice received restraint stress or no stress for 6 hours, and then RNA was extract from peripheral blood for transcriptome sequencing.