Definition of adverse events.
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Abbreviations: ULN, upper limit of normal; AST, aspartate aminotransferase; ALT, alanine aminotransferase; CK, creatinine phosphokinase.*Modified from Bellomo et al. 2004 [30].†Criteria used in Klepper MJ and Covert B. 2010 [31].‡Criteria used in Guidance of FDA. 2009 [32]. Increase of one or both of AST and ALT was counted as one event.§Criteria used in Pasternak RC et al. 2002 [33].
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2015-12-02
