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NOD genetic variation influences ab/gd lineage decisions when TCRa is prematurely expressed, but not the process of negative selection.

ChEBI2012-01-10 更新2026-07-21 收录

T细胞谱系决定

免疫遗传调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-34936 数据链接链接失效反馈

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NOD genetic variation influences ab/gd lineage decisions when TCRa is prematurely expressed, but not the process of negative selection.

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创建时间：

2012-01-10

免疫遗传调控

增强子功能变异

Research has shown that non‑coding single nucleotide polymorphisms (SNPs) can modulate gene expression by enhancing or disrupting transcription‑factor binding sites. Leveraging whole‑genome sequencing

Figshare2025-04-23 更新110

Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci

免疫遗传调控

等位基因动态表达

Here we characterized the dynamics of genetic regulatory effects at eight time points during memory CD4+ T cell activation with high depth RNA-seq in healthy individuals. We discovered widespread dyna

NIAID Data Ecosystem70

Tcf1 regulates T lymphocyte lineage fidelity through its target genes Gata3 and Bcl11b. Mus musculus

T细胞谱系决定

转录因子调控网络

T cell factor 1 (Tcf1) is the first T cell‒specific protein induced in multipotent progenitors following Notch signaling in the thymus, leading to the activation of two major target genes, Gata3 and B

NIAID Data Ecosystem60

Immune Variation Project (ImmVar) [CD4]. Homo sapiens

T细胞转录组学

免疫遗传调控

Gene expression profiling of CD4 T-Cells (CD4+CD62L+) from human peripheral blood mononuclear cells (PBMCs). PBMCs were isolated from healthy individuals from the Boston area. Overall design: Over the

NIAID Data Ecosystem70

The TH1 cell lineage-determining transcription factor T-bet supresses TH2 gene expression by redistributing GATA3 away from TH2 genes [ATAC-seq]. The TH1 cell lineage-determining transcription factor T-bet supresses TH2 gene expression by redistributing GATA3 away from TH2 genes [ATAC-seq]

T细胞谱系决定

转录因子重分布机制

Differentiation of progenitor cells into mature cell types is commonly associated with the expression of lineage-determining transcription factors (LD-TFs) specific to that lineage. In CD4+ T cells, T

NIAID Data Ecosystem70

NOD genetic variation influences ab/gd lineage decisions when TCRa is prematurely expressed, but not the process of negative selection.

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