五肽全库(ZSenithFive)高通量筛选数据

本数据集包含五肽全库对40多个靶标蛋白进行了56种活性高通量筛选的相关数据及其处理结果，旨在为多肽药物发现提供支持。该数据集的核心数据来源于通过384孔板进行的高通量筛选实验。实验过程中，每个384孔板均包含多种80环肽，通过两次读数和数据处理，评价每个80环肽的筛选表现。数据处理过程考虑了异常值、板间差异等因素，通过计算减小其对读数的影响。计算结果一定程度上可以反映每个80环肽的相对活性，为识别具有潜在药物活性的80环肽提供帮助，为后续的药物开发和优化提供参考依据。This dataset contains relevant data and processed results from 56 high-throughput activity screening assays against over 40 target proteins using the full pentapeptide library, aimed at supporting peptide drug discovery. The core data of this dataset originates from high-throughput screening experiments conducted with 384-well plates. Each 384-well plate in the experiment contains multiple 80-membered cyclic peptides, and the screening performance of each such peptide is evaluated through two rounds of readings and subsequent data processing. The data processing workflow accounts for factors such as outliers and inter-plate variations, and mitigates their impact on assay readouts via computational approaches. The resulting computational data can reflect the relative activity of each 80-membered cyclic peptide to a certain extent, aiding in the identification of cyclic peptides with potential pharmaceutical activity and providing a reliable reference for subsequent drug development and optimization.

搜集汇总

数据集介绍

特点

该数据集为多肽药物的初步筛选提供了基础数据，包含80环肽的高通量筛选结果，旨在支持多肽药物发现。数据集经过严格的数据处理，提高了筛选结果的准确性和可靠性，适用于多肽药物的初步筛选、数据校正和技术验证。