PAML analysis of primate NHEJ genes.

aEach analysis was performed on a dataset consisting of 20 primate sequences (for species list see Table S1), with the exception of the Artemis (due to deletions/missing sequence in two species) and NBS1 “hominoids only” analyses. See Table S6 (Artemis) and Table S4 (NBS1) for lists of primates used in these analyses.
bTwice the difference in the natural logs of the likelihoods (2Δl) of the two models (M8a-M8) being compared. The p-value indicates the confidence with which the null model (M8a) can be rejected in favor of the model of positive selection (M8).
cdN/dS value of the class of codons evolving under positive selection in M8, and the percent of codons falling in that class.
dCodons assigned to the class evolving under positive selection in M8 with a posterior probability >0.90 by naive empirical bayes (NEB) analysis (* p>0.95, ** p>0.99). Coordinates correspond to the human protein.