Rat model of breast cancer to dissect mechanisms of immune escape and immunotherapy sensitivity

NMU-induced sprague dawley rat model of breast cancer treated with immunotherapy to prevent tumor progression Overall design: Bulk RNA-Seq: Gene expression of FACS sorted EpCAM+, SMA+ and double negative (DN) subpopulations from tumors from NMU-induced mammary tumors in rats that were treated with vehicle, anti-PD-L1 antibody, TGFBR1 inhibitor and combination treatment.