Crystal structure of 1-((4-(3-(trifluoromethyl)-6,7-dihydropyrano(4,3- c(pyrazol-1(4H)-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.6A resolution.

Crystal structure of 1-((4-(3-(trifluoromethyl)-6,7-dihydropyrano(4,3- c(pyrazol-1(4H)-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.6A resolution. Descriptor: 1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ... Authors: Ward, S.E, Harries, M, Aldegheri, L, Austin, N.E, Ballantine, S, Ballini, E, Bradley, D.M, Bax, B.D, Clarke, B.P, Harris, A.J, Harrison, S.A, Melarange, R.A, Mookherjee, C, Mosley, J, DalNegro, G, Oliosi, B, Smith, K.J, Thewlis, K.M, Woollard, P.M, Yusaf, S.P. Deposit date: 2010-11-10 Release date: 2011-04-06 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of Ampa Receptor Positive Allosteric Modulators. J.Med.Chem., 54, 2011

分辨率为1.6埃的、结合了1-({4-[3-(三氟甲基)-6,7-二氢吡喃并[4,3-c]吡唑-1(4H)-基]苯基}甲基)-2-吡咯烷酮与谷氨酸的大鼠谷氨酸受体2（Rat GluA2 receptor）配体结合域的晶体结构。
标识符：1-({4-[3-(三氟甲基)-6,7-二氢吡喃并[4,3-c]吡唑-1(4H)-基]苯基}甲基)-2-吡咯烷酮、谷氨酸受体2、谷氨酸……
作者：Ward, S.E.、Harries, M.、Aldegheri, L.、Austin, N.E.、Ballantine, S.、Ballini, E.、Bradley, D.M.、Bax, B.D.、Clarke, B.P.、Harris, A.J.、Harrison, S.A.、Melarange, R.A.、Mookherjee, C.、Mosley, J.、DalNegro, G.、Oliosi, B.、Smith, K.J.、Thewlis, K.M.、Woollard, P.M.、Yusaf, S.P.
入库日期：2010-11-10
发布日期：2011-04-06
最后修改日期：2024-10-16
实验方法：X射线衍射（1.6 Å）
引用文献：《膜结合离子通道靶点的先导优化与晶体学整合：一类新型AMPA受体正变构调节剂的发现》，《药物化学杂志》（J.Med.Chem.），2011年，第54卷。