Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

<strong>Introduction</strong> These are the <em>Summary Level-data</em> as presented in: "Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits". Eur J Hum Genet. 2019 Jan 24. doi: 10.1038/s41431-018-0295-z.<em> [Epub ahead of print]</em> If you use these data please cite the corresponding manuscript, which can be downloaded here: https://rdcu.be/bh8mu. When you have any questions or comments regarding this study or these files, please contact me via: Jessica van Setten, PhD | <em>Department of Cardiology, University Medical Center Utrecht, Utrecht University</em> | j.vansetten [at] umcutrecht [dot] nl <strong>Files and description</strong> There are four files available: RR_summary_Sept2018.txt.gz - gzipped file containing all the (unfiltered) meta-analysis results for RR interval PR_summary_Sept2018.txt.gz - gzipped file containing all the (unfiltered) meta-analysis results for PR interval QT_summary_Sept2018.txt.gz - gzipped file containing all the (unfiltered) meta-analysis results for QT interval QRS_summary_Sept2018.txt.gz - gzipped file containing all the (unfiltered) meta-analysis results for QRS duration All these files have the same lay-out and are gzipped. The reference used for meta-analysis of GWAS was Genome of the Netherlands v4. <em>SNP</em> - variantID (rsID), please note that few hundred variants do not have an rsID, but are NA instead. These can still be identified by chromosome and position. <em>CHR</em> - chromosome numbers [1-22 and X]. <em>POS</em> - base pair position, hg19 / build37. <em>CODED_ALLELE</em> - coded allele, <em>i.e.</em> the effect allele, as represented (and harmonized) across cohorts. Note that this is not necessarily the minor allele. <em>NON_CODED_ALLELE</em> - the other allele, <em>i.e.</em> the non-effect allele. <em>CODED_ALLELE_FREQ</em> - coded allele frequency, <em>i.e.</em> the effect allele frequency. Note that this is not necessarily the minor allele frequency. <em>BETA</em> - beta from the fixed-effects model. <em>SE </em>- standard error from the fixed-effects model. <em>P </em>- P-value from the fixed-effects model. <em>NEAREST_GENE</em> - the gene closest to the respective variant.